If you were so lucky to draft #1 and got Christian McCaffrey, you’re smiling at the matchup with a Raider D that did not strike fear into any teams’ hearts last year. Derrick Henry should continue his 2019 roll against a Denver D that has been hit hard with injuries. Beware Saquon Barkley against the intense Steeler D. Here are the rankings for Week 1:
| RANK | PLAYER (TEAM) | MATCHUP |
| 1 | Christian McCaffrey (CAR) | vs. LV |
| 2 | Ezekiel Elliott (DAL) | at LAR |
| 3 | Derrick Henry (TEN) | at DEN |
| 4 | Josh Jacobs (LV) | at CAR |
| 5 | Dalvin Cook (MIN) | vs. GB |
| 6 | James Conner (PIT) | at NYG |
| 7 | Austin Ekeler (LAC) | at CIN |
| 8 | Joe Mixon (CIN) | vs. LAC |
| 9 | Saquon Barkley (NYG) | vs. PIT |
| 10 | Clyde Edwards-Helaire (KC) | vs. HOU |
| 11 | Aaron Jones (GB) | at MIN |
| 12 | Alvin Kamara (NO) | vs. TB |
| 13 | Kenyan Drake (ARI) | at SF |
| 14 | Nick Chubb (CLE) | at BAL |
| 15 | Chris Carson (SEA) | at ATL |
| 16 | Raheem Mostert (SF) | vs. ARI |
| 17 | Mark Ingram II (BAL) | vs. CLE |
| 18 | Todd Gurley (ATL) | vs. SEA |
| 19 | Jonathan Taylor (IND) | at JAC |
| 20 | David Johnson (HOU) | at KC |
| 21 | Boston Scott (PHI) | at WAS |
| 22 | Marlon Mack (IND) | at JAC |
| 23 | Cam Akers (LAR) | vs. DAL |
| 24 | Antonio Gibson (WAS) | vs. PHI |
| 25 | Le’Veon Bell (NYJ) | at BUF |
| 26 | Melvin Gordon (DEN) | vs. TEN |
| 27 | Kareem Hunt (CLE) | at BAL |
| 28 | James White (NE) | vs. MIA |
| 29 | Devin Singletary (BUF) | vs. NYJ |
| 30 | Ronald Jones II (TB) | at NO |
| 31 | Sony Michel (NE) | vs. MIA |
| 32 | James Robinson (JAC) | vs. IND |
| 33 | J.K. Dobbins (BAL) | vs. CLE |
| 34 | Zack Moss (BUF) | vs. NYJ |
| 35 | David Montgomery (CHI) | at DET |
| 36 | Phillip Lindsay (DEN) | vs. TEN |
| 37 | Jordan Howard (MIA) | at NE |
| 38 | Darrel Williams (KC) | vs. HOU |
| 39 | Corey Clement (PHI) | at WAS |
| 40 | Chris Thompson (JAC) | vs. IND |
| 41 | Latavius Murray (NO) | vs. TB |
| 42 | Tarik Cohen (CHI) | at DET |
| 43 | Rex Burkhead (NE) | vs. MIA |
| 44 | Kerryon Johnson (DET) | vs. CHI |
| 45 | Leonard Fournette (TB) | at NO |
| 46 | Malcolm Brown (LAR) | vs. DAL |
| 47 | Joshua Kelley (LAC) | at CIN |
| 48 | Matt Breida (MIA) | at NE |
| 49 | D’Andre Swift (DET) | vs. CHI |
| 50 | Tevin Coleman (SF) | vs. ARI |
| 51 | Duke Johnson (HOU) | at KC |
| 52 | Tony Pollard (DAL) | at LAR |
| 53 | Alexander Mattison (MIN) | vs. GB |
| 54 | Jerick McKinnon (SF) | vs. ARI |
| 55 | Carlos Hyde (SEA) | at ATL |
| 56 | Benny Snell Jr. (PIT) | at NYG |
| 57 | Adrian Peterson (DET) | vs. CHI |
| 58 | Chase Edmonds (ARI) | at SF |
| 59 | Frank Gore (NYJ) | at BUF |
| 60 | Darrell Henderson (LAR) | vs. DAL |
| 61 | Justin Jackson (LAC) | at CIN |
| 62 | Brian Hill (ATL) | vs. SEA |
| 63 | Jamaal Williams (GB) | at MIN |
| 64 | J.D. McKissic (WAS) | vs. PHI |
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